Status:
UNKNOWN
Effects of Nutritional Fat on the Growth of Intestinal E. Coli
Lead Sponsor:
University of Zurich
Conditions:
Escherichia Coli Infections
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Recent experiments in the lab of Prof. WD Hardt revealed, that in mice, 24 h exposure to a high-fat diet results in a breakdown of colonization resistance against Salmonella typhimurium. Mechanistic e...
Detailed Description
Infectious diarrhea causes substantial morbidity in Western countries and the developing world and leads to the use of considerable health resources. Antibiotic resistance continues to increase, poten...
Eligibility Criteria
Inclusion
- Individuals free of abdominal complaints or symptoms
- Written informed consent
- Age 18 - 85 years
- Working at ETH Zurich or University of Zurich and trained and experienced in handling -80°C freezers at biosafety level 2.
Exclusion
- Previous history of gastrointestinal disease or surgery (excludes appendectomy, hernia repair and surgery for anorectal disorders)
- Known diabetes mellitus, scleroderma, neurological impairment or other major diseases requiring ongoing management
- Immunesuppression
- Subjects with antibiotic therapy, proton pump inhibitors or laxatives within the last four weeks
- Pregnancy beyond week 12. "Mutaflor" intake is safe during pregnancy; however, special regulations are required to gain access to the -80°C freezers. No pregnancy test will be performed.
Key Trial Info
Start Date :
January 24 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 24 2019
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03800147
Start Date
January 24 2019
End Date
September 24 2019
Last Update
January 11 2019
Active Locations (1)
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1
Institute of Microbiology (D-BIOL), ETH Zurich
Zurich, Switzerland, 8093