Status:
UNKNOWN
Investigation of Plastic Changes in the CNS Associated With Peripheral Neuropathy
Lead Sponsor:
Wayne State University
Conditions:
Peripheral Neuropathy
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Recent neuroimaging literature on neuropathy suggests that chronic pain is characterized by learning-related and memory-related plastic changes of the central nervous system (CNS) with concomitant mal...
Detailed Description
The goal is to relate non-invasive brain imaging data to clinical parameters in order to develop a mechanistic model of CNS adaptive processes that are produced by a patient-specific disease state. Th...
Eligibility Criteria
Inclusion
- Diagnosis of a peripheral nerve disease - IPN, CIDP or CMT1A (patient group only)
- Healthy volunteers with no history of medical conditions known to afflict the nervous system will be recruited as normal controls (control group only)
- Age 18-60 (Inclusive)
- Able to undergo PET and MRI
- Patients who are not on sedative, antidepressant, sedative antihistaminic or narcotic medications.
Exclusion
- Any subject unwilling to undergo genetic testing (DNA sampling)
- Any subjects with history of conditions known to affect the PNS, such as diabetes, stroke, thyroid disease, chemotherapy, renal failure, alcohol abuse, etc.
- Subjects with abnormal physical findings suggesting peripheral nerve diseases.
- Subjects of reproductive potential, who are sexually active but unwilling and/or unable to use medically appropriate contraception, or women who are pregnant or breastfeeding
Key Trial Info
Start Date :
February 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2020
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03805893
Start Date
February 1 2019
End Date
December 31 2020
Last Update
January 16 2019
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