Status:
COMPLETED
Apathy in Late Life Depression: New Biomarkers Using Actimetry and Magnetic Resonance Imaging
Lead Sponsor:
Rennes University Hospital
Conditions:
Depression
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Old age (\> 60 years) is at high risk to develop major depression disorders (MDD). MDD doubles the risk for subsequent cognitive disorders and dementia. Apathy (i.e. the lack of motivation) is a core ...
Eligibility Criteria
Inclusion
- Patients:
- 60 years and above
- Major depressive disorder (either late-onset or early onset)
- Ambulatory settings
- Both uni and bipolar depression will be considered Healthy controls
- 60 years and above
- No psychiatric disorders, including no major depressive disorder
- No non-inclusion criteria
Exclusion
- Patients and healthy controls
- Major cognitive disorders (\< 125 on the Mattis dementia rating scale and a major cognitive disorders diagnostic according to the DSM5 (Diagnostic and Statistical Manual of Mental Disorders) criteria).
- Other neurological conditions (stroke, Parkinson's disease and seizures), severe and inflammatory disorders (ex: severe arthroses which limits movements, spondylarthritis)
- Severe sarcopenia: speed walk \< 1 meter/second
- Extrapyramidal syndrome
- High suicidal risk
- Anti-psychotic prescription
- Participant who are unable to provide clear consent, under legal protection
- MRI contra-indication
Key Trial Info
Start Date :
August 9 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 9 2023
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT03807167
Start Date
August 9 2019
End Date
February 9 2023
Last Update
March 28 2023
Active Locations (6)
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1
Centre Mémoire de Ressources et de Recherche (CMRR),
Nice, France, 06100
2
CHU Pontchaillou, Département de Radiologie et d'Imagerie Médicale
Rennes, France, 35033
3
Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte
Rennes, France
4
CHU Bretonneau, Consultations Intersectorielles de Gérontopsychiatrie
Tours, France, 37044