Status:
COMPLETED
Obesity and Endogenous Oxalate Synthesis
Lead Sponsor:
University of Alabama at Birmingham
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Obesity
Eligibility:
All Genders
19-70 years
Phase:
NA
Brief Summary
The goal of this study is to determine if obesity is associated with increased endogenous oxalate synthesis as assessed by urinary oxalate excretion, which is a known risk factor for calcium oxalate k...
Detailed Description
In this study the investigators propose to measure the excretion of urinary oxalate on a fixed diet with controlled amounts of oxalate, in individuals of varying body sizes without history of kidney s...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Age 19-70 yrs Body Mass Index \> 18.5 kg/m2 Normal fasting serum electrolytes on comprehensive metabolic profile Willing to ingest fixed diets
- Exclusion Criteria
- Chronic Kidney Disease, estimated glomerular filtration rate \< 60 ml/mn/1.73m2 Primary hyperoxaluria Liver, endocrine or renal diseases or any other condition that may influence the absorption, transport or urinary excretion of ions, which will compromise the interpretation of results, including: Cystic fibrosis, Cystinuria, Uric acid stone former, Nephrotic syndrome, Sarcoidosis, Renal tubular acidosis, Primary hyperparathyroidism, Neurogenic bladder, Urinary diversion Pregnancy or breast-feeding Incompatible dietary requirements with the study, food allergies or intolerance to any of the foods in study menus Active malignancy or treatment for malignancy within 12 months prior to screening Utilization of immunosuppressive medication Uncontrolled Hypertension or diabetes
Exclusion
Key Trial Info
Start Date :
January 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2024
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT03808090
Start Date
January 1 2013
End Date
July 31 2024
Last Update
September 19 2024
Active Locations (1)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294