Status:
COMPLETED
Fluid Challenge Infusion and Response
Lead Sponsor:
Humanitas Clinical and Research Center
Conditions:
Neurosurgery
Cardiovascular System
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
It is unclear if the rate of administration of the fluid challenge could affect the rate of fluid responsiveness. The role of this small-dose (the so called mini-FC) has been recently tested to asses...
Detailed Description
Dedicated algorithms and protocols of anaesthetic care regarding fluid therapy are key factors to prevent perioperative hypovolaemia and/or hypervolemia, which are known to increase morbidity and leng...
Eligibility Criteria
Inclusion
- Adult patients aged ≥ 18 years;
- Scheduled for elective supine neurosurgery and requiring invasive arterial monitoring;
- Glasgow coma scale 15 at recruitment
Exclusion
- Any recurrent cardiac arrhythmias;
- Reduced left (ejection fraction \<30%) or right (systolic peak velocity of tricuspid annular motion \<0.17 m/s) ventricular systolic function;
- Intra-operative use of vasopressors or inotropes before FC administration or between the first and the second bolus of fluids.
- Chronic use beta-blocking agents.
Key Trial Info
Start Date :
April 8 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2020
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT03810118
Start Date
April 8 2019
End Date
May 1 2020
Last Update
May 27 2020
Active Locations (1)
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1
Humanitas Research Hospital
Rozzano, Milano, Italy, 20089