Status:
RECRUITING
Cold-induced Brown Fat Activation and Hepatic Steatosis
Lead Sponsor:
Medical University of Vienna
Conditions:
Non-Alcoholic Fatty Liver Disease
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
In the recent years, research on brown adipose tissue (BAT) revealed that larger amounts as well as higher activity thereof are associated with a favourable metabolic phenotype. Longitudinal studies w...
Eligibility Criteria
Inclusion
- body mass index 28 - 40 kg/m\^2
- hepatic lipid content \> 10 %
Exclusion
- endocrine disease, except treated hypo-/hyperthyroidism and hypertriglyceridemia (\<500 mg/dl) and untreated type II diabetes mellitus (fasting glucose \< 140 mg/dl)
- use of beta-blockers, alpha-blockers and rilmenidine
- chronic kidney disease
- inflammatory bowel disease
- active malignant disease
- autoimmune disease
- chronic alcohol abuse or alcohol consumption greater than 30g/d for men or 20 g/d for women
- transferrin saturation \> 40%
- serum alpha-1 antitrypsin \< 90 mg/dl
- serum ceruloplasmin \< 20 mg/dl
- positive serology for autoimmune hepatitis
- positive hepatitis serology
- liver cirrhosis
- portal hypertension
- pregnancy
- contraindications for magnetic resonance imaging
Key Trial Info
Start Date :
January 21 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT03811236
Start Date
January 21 2019
End Date
December 1 2026
Last Update
March 13 2024
Active Locations (1)
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1
Medical University of Vienna
Vienna, Austria, 1090