Status:
UNKNOWN
Search for Biomarkers of Infection and Inflammation in Patients With Acute Stroke.
Lead Sponsor:
Jakob Ström
Collaborating Sponsors:
Örebro University, Sweden
Conditions:
Stroke, Acute
Pneumonia, Bacterial
Eligibility:
All Genders
18+ years
Brief Summary
This study will look for new biomarkers of infection and evaluate current biomarkers of infection in stroke patients. Patients with acute stroke will be monitored with daily blood samples for seven da...
Detailed Description
Rationale: Stroke is one of the leading causes of death globally, and infections after stroke contribute to a large part of the stroke-related mortality. The current study, which has a prospective, ob...
Eligibility Criteria
Inclusion
- Symptoms and radiology consistent with acute cerebral infarction or atraumatic intracerebral hemorrhage.
- National Institutes of Health Stroke Scale (NIHSS) ≤5; mild stroke (n=25), NIHSS ≤10 and ≥ 6; moderate stroke (n=25) or NIHSS ≥ 11; severe stroke (n=150)
- Onset of symptoms less than 48 hours before first study blood sampling.
Exclusion
- Symptoms and radiology consistent with acute cerebral infarction but full reversal of symptoms within 24 hours of onset. (i.e. transient ischemic attack, TIA)
- Hemoglobin less than 90 g/l.
- Ongoing inflammatory disease, such as rheumatoid arthritis or active inflammatory bowel disease.
- Inability to undergo MRI scan (only patients with NIHSS ≤10 will be excluded by this criteria)
Key Trial Info
Start Date :
January 15 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2025
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03812666
Start Date
January 15 2019
End Date
July 1 2025
Last Update
November 18 2023
Active Locations (1)
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1
Örebro University Hospital
Örebro, Örebro County, Sweden, 701 85