Status:
COMPLETED
Testing Insect Repellents Against Musca Sorbens, the Vector of Trachoma
Lead Sponsor:
London School of Hygiene and Tropical Medicine
Collaborating Sponsors:
Federal Minstry of Health of Ethiopia
Oromia Regional Health Bureau, Ethiopia
Conditions:
Trachoma
Eligibility:
All Genders
3-65 years
Phase:
PHASE2
Brief Summary
Musca sorbens, a fly that feeds from ocular and nasal discharge on humans, is thought to be the vector of trachoma. We are developing methods of fly control that specifically target this species, in t...
Detailed Description
Introduction Trachoma Trachoma, a Neglected Tropical Disease (NTD), is the commonest infectious cause of blindness globally, affecting some of the world's poorest communities. Trachoma is caused by ...
Eligibility Criteria
Inclusion
- Laboratory trial eligibility criteria
- Participant is aged \> 18 years and \< 65 years and in good health
- Participant has a good understanding of the procedures of the study and agrees to abide to these procedures
- Participant is able to communicate well with the investigator, and attend the laboratory for all aspects of the laboratory studies
- Participant has no known adverse reactions, or evidence at screening of adverse reactions, to the commercially available repellents DEET, PMD, IR3535, Picaridin or Permethrin, or to Vanilla
- Participant has no known history of skin allergies or hypersensitivity to topical creams
- Participant agrees to a pre-trial skin reactivity test for all the repellents that will be used in the trial
- If in the event of the participant experiencing an adverse reaction to a repellent during the trial, the participant agrees to inform his/her general practitioner and seek appropriate treatment if necessary
- Participant is willing to allow laboratory-reared Musca sorbens flies to land and crawl on their arm, during the modified arm-in-cage assay, for periods of up to ten minutes at a time
- Participant agrees not to use any perfumed or scented product, including bathing products, for a 24-hour period before each laboratory session
- Participant has signed informed consent
- Participant is not a smoker, and will agree to refraining from smoking for the 12 hours before each laboratory trial
- Field trial eligibility criteria
- Participant lives in the designated study site
- Participating households must be within a one-hour drive of Feya General Hospital
- Participant considers themselves to be in good health, as does the parent or guardian
- Participant is aged \> 3 years and \< 12 years
- Participant has a good understanding of the procedures of the study and agrees to abide to these procedures
- The parent or guardian of the participant has a good understanding of the procedures of the study and agrees to abide to these procedures
- Participant is able to communicate well with the investigator or fieldworker who is conducting the study
- Participant has no known adverse reactions to the commercially available repellents DEET, PMD, IR3535, Picaridin or Permethrin, or to Vanilla
- Participant has no known history of skin allergies or hypersensitivity to topical creams
- Participant agrees to a pre-trial skin reactivity test for all the repellents that will be used in the trial
- If in the event of the participant experiencing an adverse reaction to a repellent during the trial, the participant can request medical advice from the Stronger-SAFE field team nurses if they wish
- Participant is willing to sit still on a chair outside their house, for sequential periods of up to ten minutes, allowing wild fly contact and landing on the body and face, as much as possible without disturbing fly behaviour
- Participant agrees not to use any perfumed or scented product, including bathing products, for a 24-hour period before each laboratory session
- Able and willing to give fully informed assent
- The parent or guardian has signed informed consent
Exclusion
Key Trial Info
Start Date :
January 10 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 23 2019
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT03813069
Start Date
January 10 2019
End Date
December 23 2019
Last Update
April 8 2020
Active Locations (2)
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1
Fred Hollows Foundation
Addis Ababa, Ethiopia
2
London School of Hygiene and Tropical Medicine
London, United Kingdom, WC1E 7HT