Status:
UNKNOWN
Intestinal Microbiota and Vitamin K Levels in PXE Patients (IMPROVE Study)
Lead Sponsor:
University Hospital, Angers
Collaborating Sponsors:
Maastricht University
Biofortis Mérieux NutriSciences
Conditions:
Pseudoxanthoma Elasticum
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study aims to demonstrate a potential association between gut microbiota composition, plasma levels of various forms of vitamin K, and severity of clinical manifestations of Pseudoxanthoma Elasti...
Detailed Description
Vitamin K deficiency contributes to pathological calcification which underlies the clinical picture of pseudoxanthoma elasticum (PXE), an inherited autosomal recessive disease. A substantial proportio...
Eligibility Criteria
Inclusion
- Patients with phenotypically and genetically (ABCC6) proven PXE
- Aged over 18 years
- Written consent obtained for Angers University Hospital (France) PXE bio-collection
Exclusion
- Patients under the age of 18
- Patients unwilling to participate in the study, or unable to sign the bio-collection consent form
Key Trial Info
Start Date :
January 21 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 30 2020
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03813550
Start Date
January 21 2019
End Date
January 30 2020
Last Update
February 4 2019
Active Locations (3)
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1
Biofortis Mérieux NutriSciences
Saint-Herblain, Pays de la Loire Region, France, 44800
2
Department of Dermatology, University Hospital of Angers
Angers, Pays de Loire, France, 49933
3
Department of Biochemistry, University Maastricht
Maastricht, Netherlands, 6229