Status:
UNKNOWN
Impact of Air Pollution on Chronic Respiratory Diseases
Lead Sponsor:
Seoul National University Hospital
Collaborating Sponsors:
Seoul National University Bundang Hospital
SMG-SNU Boramae Medical Center
Conditions:
Chronic Obstructive Pulmonary Disease
Asthma
Eligibility:
All Genders
19+ years
Brief Summary
The aim of this study is to evaluate the impact of air pollution on the occurrence and clinical course of chronic respiratory diseases, and discover new biomarkers from various devices such as CT imag...
Detailed Description
Normal people (n=90) and patients with chronic respiratory diseases (chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, n=90 for each disease) will be enrolled at 5 differen...
Eligibility Criteria
Inclusion
- Normal: People with no lung lesions in chest X-ray and St. George's Respiratory Questionnaire score \<25, and post bronchodilator FEV1/FVC (forced expiratory volume at one second/forced vital capacity) \>= 0.7 and FEV1 \>= 80% and FVC \>= 80%.
- Chronic obstructive pulmonary disease: Patients with over 10 pack-years of smoking history and post bronchodilator FEV1/FVC \<0.7 and FEV1 \< 80%, and no other reason for decline of lung function.
- Asthma: Patients with FEV1/FVC \< 0.85 and increase in over 12% and 200mL of FEV1 by bronchodilator inhalation. Patients with P20 \< 16mg/dL by bronchial provocation test.
- Idiopathic pulmonary fibrosis: Shows usual interstitial pneumonia according to chest CT and has no other reasons such as systematic diseases or medication history.
Exclusion
- Subjects who refused for enrollment in the study
- Subjects who experienced an acute exacerbation within 1 month.
- Subjects under age of 19.
Key Trial Info
Start Date :
January 25 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2021
Estimated Enrollment :
360 Patients enrolled
Trial Details
Trial ID
NCT03813810
Start Date
January 25 2019
End Date
December 1 2021
Last Update
January 23 2019
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