Status:
UNKNOWN
Efficacy of Low Dose Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
Lead Sponsor:
Samsung Changwon Hospital
Conditions:
Peptic Ulcer Hemorrhage
Peptic Ulcer, Acute With Hemorrhage
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
We prepare this study to compare the efficacy of intermittent intravenous PPI infusion (relatively low dose PPI therapy) than continous PPI infusion method. Our hypothesis is that intermittent (40mg a...
Detailed Description
Background Current guidelines recommend an intravenous bolus dose of a proton pump inhibitor(PPI) followed by continuous PPI infusion after endoscopic therapy in patients with high-risk peptic ulcer b...
Eligibility Criteria
Inclusion
- Patients aged 18 years or older who had undergone gastroscopy for melena, hematochezia or hematemesis due to bleeding peptic ulcers were eligible. These eligible patients were required to have a peptic ulcer with bleeding on emergency endoscopy performed within 24 hours after hospitalization
Exclusion
- refusal of endoscopy, gastrointestinal malignancy, Mallory-Weiss syndrome, variceal bleeding, bleeding d/t endoscopic procedure, small bowel bleeding, serious medical disease
Key Trial Info
Start Date :
April 15 2016
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2021
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03814421
Start Date
April 15 2016
End Date
October 31 2021
Last Update
October 22 2020
Active Locations (1)
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1
Samsung Changwon Hospital
Changwon, Gyeongsangnam-do, South Korea, 51353