Status:
UNKNOWN
Circulating Osteocalcin-positive Cells in Breast Cancer Bone Metastasis
Lead Sponsor:
Seoul National University Hospital
Collaborating Sponsors:
National Cancer Center, Korea
Conditions:
Breast Neoplasms
Bone Metastases
Eligibility:
FEMALE
20+ years
Brief Summary
Bone metastasis (i.e. cancer cell spreading to bone) is the major clinical problem of advanced breast cancer patients. Bone metastasis is not curable nor preventable. Currently available therapeutic a...
Detailed Description
Bone is the most common site of breast cancer metastasis, and the skeletal-related events (SRE) of bone metastasis such as pathologic fractures, cord compression, hypercalcemia and severe pain, accoun...
Eligibility Criteria
Inclusion
- Stages 2A-4 breast cancer patients who are subject to adjuvant chemotherapy or radiotherapy
- 20 years of age or greater
- Female
- Ability to understand the study objectives and willingness to sign written consent
- ECOG status 0, 1 or 2
Exclusion
- History of primary cancer diagnosis in other sites than breast within 5 years
- Diseases of bone metabolism including primary hyperparathyroidism, Paget's disease, osteomalacia, osteogenesis imperfecta
- ECOG status 3 or 4
- Retraction of written consent
Key Trial Info
Start Date :
July 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03814811
Start Date
July 1 2017
End Date
December 31 2021
Last Update
January 24 2019
Active Locations (2)
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1
Korea University Anam Hospital
Seoul, South Korea, 02841
2
Seoul National University Hospital
Seoul, South Korea, 03080