Status:
UNKNOWN
Intra-arterial Infusion Chemotherapy Combined With Sodium Bicarbonate for Unresectable Gastric Cancer
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions:
Successful Conversion Rate of Operation
Unresectable Gastric Cancer
Eligibility:
All Genders
18-75 years
Phase:
EARLY_PHASE1
Brief Summary
This project intends to compare the clinical effects and side effects of three kinds of treatment methods in the treatment of unresectable gastric cancer by intra-arterial catheter infusion chemothera...
Eligibility Criteria
Inclusion
- Patients aged 18 to 75 years;
- Ultrasound gastroscopy or imaging (CT) can diagnose potentially unresectable gastric cancer (T4a-bN2-3M0) with indications of neoadjuvant chemotherapy or transformation therapy;
- Pathological diagnosis of gastric cancer;
- No contraindication of chemotherapy;
- Patients who did not undergo chemotherapy or were diagnosed for the first time.
Exclusion
- Those who fail to comply with the requirements of the trial, obviously violate this regimen, or change to other regimens in the course of treatment;
- The life expectancy of patients with extensive systemic metastasis is less than 3 months;
- Leukocyte count is less than 2\*109/L and platelet count is less than 75\*10\^9/L;
- Severe heart, liver and kidney diseases, unable to tolerate chemotherapy;
- Patients without gastric cancer complications such as massive gastrointestinal bleeding and perforation need to be treated in emergency department;
- Patients with distant metastasis (excluding group 16 lymph node metastasis);
- Patients with other tumors, with a history of malignant tumors (excluding early primary cancers);
- The patient himself asked to withdraw from the trial;
- Researchers believe that patients are not suitable for this study.
Key Trial Info
Start Date :
February 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2020
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT03822130
Start Date
February 1 2019
End Date
December 31 2020
Last Update
February 20 2019
Active Locations (1)
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1
The Second affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310000