Status:
COMPLETED
Choline Uptake Study
Lead Sponsor:
Wageningen University and Research
Collaborating Sponsors:
AAK
Conditions:
Choline Uptake
Kinetics
Eligibility:
All Genders
30-70 years
Phase:
NA
Brief Summary
The study is a randomised, cross-over, double blind, controlled trial in which study participants will visit the research facility on two occasions under fasting conditions with a washout period of on...
Detailed Description
Choline is water-soluble vitamin-like essential nutrient. It is made in small amounts by the liver, but humans need to receive choline through the diet or by supplementation for proper health. Pregnan...
Eligibility Criteria
Inclusion
- Apparently healthy men and women
- Age between 30 and 70 years
- Body mass index (BMI) between 18.5 and 24.9 kg/m2
- Having veins suitable for blood sampling via a catheter (judged by study nurse/ medical doctor)
Exclusion
- Any metabolic, gastrointestinal, inflammatory or chronic disease (such as diabetes, anaemia, hepatitis, cardiovascular disease)
- History of gastro-intestinal surgery or having (serious) gastro-intestinal complaints
- History of liver dysfunction (cirrhosis, hepatitis) or liver surgery
- Kidney dysfunction (self-reported)
- Use of medication that may influence the study results,
- such as laxatives, stomach protectors and drugs that can affect intestinal motility.
- Use of choline or fish oil supplements
- Reported slimming, medically prescribed or vegan diet
- Current smokers
- Alcohol intake ≥4 glasses of alcoholic beverages per day
- Pregnant, lactating or wishing to become pregnant in the period of the study (self-reported)
- Abuse of illicit drugs
- Food allergies for products that we use in the study
- Participation in another clinical trial at the same time
- Being an employee of the department Consumer Science \& Health group of Wageningen Food \& Biobased Research and/or Human Nutrition and Health
Key Trial Info
Start Date :
February 5 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 19 2019
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT03822169
Start Date
February 5 2019
End Date
February 19 2019
Last Update
April 12 2019
Active Locations (1)
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1
Stichting Wageningen Research
Wageningen, Gelderland, Netherlands, 6708 WG