Status:
WITHDRAWN
Lectine Pathway in Unstable Carotid Plaque
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
Carotid Artery Plaque
Mannose-Binding Lectin Complement Pathway
Eligibility:
All Genders
40-80 years
Brief Summary
The study is aimed to investigate the possible role of lectin pathway - an alternative pathway of complement activation - in affecting stability of carotid atherosclerotic plaques and the possible cor...
Detailed Description
In addition to the known hemodynamic criteria, instable carotid plaques can be responsible for brain ischemia, therefore is paramount to identify preoperatively possible markers of plaque instability....
Eligibility Criteria
Inclusion
- patients undergone elective or urgent carotid endoarterectomy (CEA) for internal carotid stenosis \>70% (assessed by velocimetric criteria) with or without neurologic symptoms
Exclusion
- recent (\<20 days) major/minor stroke with positive CT scan
- absolute contraindications to surgery (cardiac, respiratory, anesthesiologic risk)
Key Trial Info
Start Date :
April 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 28 2021
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03822195
Start Date
April 1 2019
End Date
February 28 2021
Last Update
July 24 2020
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