Status:
ACTIVE_NOT_RECRUITING
Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis
Lead Sponsor:
Ann & Robert H Lurie Children's Hospital of Chicago
Conditions:
Eosinophilic Esophagitis
Eligibility:
All Genders
1-18 years
Brief Summary
The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the ...
Detailed Description
The diagnosis, assessment of recurrence of inflammation, response to treatment and remission in EoE are all currently based on histological evaluation of upper endoscopic pinch esophageal biopsies. Ob...
Eligibility Criteria
Inclusion
- Patient ages 1-18 undergoing upper endoscopy for suspected esophageal disease or esophageal inflammation or has histologically confirmed esophageal inflammation may be included in this study
Exclusion
- Patients with a history or current diagnosis of esophageal malignancy or subjects with graft versus host disease will be excluded from the study.
- Patients that are considered at high risk for biopsies at the discretion of the child's physician and/or the researcher
- Patients with known bleeding disorders or patients with illnesses where bleeding would pose a threat to their health
- Diagnosis other than Eosinophilic Esophagitis (EoE) i.e. Inflammatory Bowel Disease (IBD), Gastroesophageal Reflux Disease (GERD)
Key Trial Info
Start Date :
February 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2025
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT03822325
Start Date
February 1 2011
End Date
November 1 2025
Last Update
November 15 2024
Active Locations (2)
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1
Ann & Robert H Lurie Children's Hospital of Chicago
Chicago, Illinois, United States, 60611
2
University of Illinois at Chicago (UIC)
Chicago, Illinois, United States, 60612