Status:
UNKNOWN
Pneumoperitoneum Preconditioning for the Prevention of Renal Function After Laparoscopic Partial Nephrectomy
Lead Sponsor:
Nanjing First Hospital, Nanjing Medical University
Conditions:
Ischemia Reperfusion Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The present study is designed to investigate the short-term and long-term renoprotective role of pneumoperitoneum preconditioning in patients undergoing laparoscopic partial nephrectomy.
Detailed Description
Renal ischemia reperfusion injury (IRI) is an inevitable event in patients undergoing laparoscopic partial nephrectomy (LPN), which can obviously affect the post-operational renal function. Pneumoperi...
Eligibility Criteria
Inclusion
- Male and female patients aged 18 years and older;
- Patients with renal tumours (whether benign or malignant) and accept laparoscopic partial nephrectomy as the surgical method;
- The renal tumor must be stage T1a (assessed by MRI/CT), and tumor≤4cm in diameter;
- Unilateral renal tumour, and another contralateral renal function reveal normal (renal function \>40% as determined by radionuclide scintigraphy);
- Patients volunteer for this study and provided written informed consent.
Exclusion
- Large tumour (tumor\>4cm in diameter);
- Severe renal insufficiency (glomerular filtration rate, GFR\<30 ml/min/1.73m2) or needing preoperative dialysis (hemodialysis or peritoneal dialysis);
- Patients severe cardiopulmonary dysfunction;
- Pregnancy Women;
- Patients with other malignant tumours;
- Patients who have had a renal transplantation;
- Patients with a history of other abdominal viscera operations within one year (open or under laparoscope);
- American Society of Anesthesiologists (ASA)\>Ⅲ.
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2023
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT03822338
Start Date
January 1 2021
End Date
June 1 2023
Last Update
October 3 2022
Active Locations (1)
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1
Nanjing First Hospital
Nanjing, Jiangsu, China, 210006