Status:
RECRUITING
Etiology and Treatment of Neonatal Seizure
Lead Sponsor:
Children's Hospital of Fudan University
Conditions:
Seizures
Seizure Disorder
Eligibility:
All Genders
Up to 12 years
Brief Summary
Genetic diagnosis for neonates suffering from epilepsy has important implications for treatment, prognosis, and development of precision medicine strategies. Investigator performed exome sequencing (E...
Detailed Description
Seizure is one of the most common neurological conditions in neonates, and has substantial impact on patients'quality of life and social integration. Epileptic encephalopathy is characterized by refra...
Eligibility Criteria
Inclusion
- severe seizures in neonates or generalized epilepsy or intractable epilepsy in infancy with generalized tonic-clonic seizures,
- seizures onset before 1 year of age,
- epileptic syndromes/epileptic-encephalopathies with unknown etiology.
Exclusion
- Patients were excluded if they had traumas, central nervous system infections, hypoxic-ischemic encephalopathy, vascular events, systemic infections, and diagnosed metabolic disorders, and pathogenic copy-number variants were identified using array-based comparative genomic hybridization (CGH).
Key Trial Info
Start Date :
August 8 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT03822741
Start Date
August 8 2016
End Date
December 30 2026
Last Update
October 21 2024
Active Locations (1)
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1
Children Hospital of Fudan University
Shanghai, Shanghai Municipality, China, 201102