Status:
COMPLETED
Hippocampal Memory Circuits in Delusions
Lead Sponsor:
NYU Langone Health
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Psychosis
Eligibility:
All Genders
16-35 years
Brief Summary
This study will investigate dentate gyrus (DG) and hippocampal CA3 sub field function, using the pattern separation paradigm, as reflected by the difference in brain activation in response to same-as-...
Eligibility Criteria
Inclusion
- Males and females 16 to 35 years of age, inclusive, at the time of informed consent
- Right-handed
- Must have experienced a first episode of non-affective psychosis over the past five years
- Must exhibit a persistence of delusions for at least 4 days per week for at least 4 weeks in the absence of psychotomimetic substance use or other potential organic etiologies, including epilepsy or significant head trauma.
- Must score at least a 2 (mild to moderate) on the "Amount of preoccupation with delusions" and "Conviction" items on the Psychotic Symptom Rating Scale (PSYRATS).
Exclusion
- Diagnosis of major mood disorder or other Axis I disorder other than Schizophrenia, Schizoaffective Disorder or Schizophreniform Disorder.
- Significant medical or neurological illness by history or physical exam including seizure disorder, history of loss of consciousness related to head trauma or developmental disorder including mental retardation.
- Metal implants, pacemaker, or other metal in the body or medicinal patch.
- History of claustrophobia.
- Currently taking any anti psychotic medication (within 4 weeks).
Key Trial Info
Start Date :
July 13 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 12 2023
Estimated Enrollment :
212 Patients enrolled
Trial Details
Trial ID
NCT03822910
Start Date
July 13 2019
End Date
August 12 2023
Last Update
April 30 2024
Active Locations (3)
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1
New York Langone Health
New York, New York, United States, 11375
2
Shanghai Mental Health Center
Shanghai, China
3
Suzhou Guangji Hospital
Suzhou, China