Status:
UNKNOWN
Postpartum NSAIDS and Maternal Hypertension
Lead Sponsor:
University of Southern California
Conditions:
Preeclampsia
Gestational Hypertension
Eligibility:
FEMALE
18+ years
Phase:
PHASE4
Brief Summary
Previous studies have suggested that NSAID use causes an increase in blood pressure. Further, blood pressure elevation has been noted in women with pregnancy related hypertensive disease during the po...
Detailed Description
The objective of this study is to determine whether the withholding of NSAID use is associated with a clinically significant decrease in postpartum hypertension in women with antepartum hypertension. ...
Eligibility Criteria
Inclusion
- Women 18 years or older delivering at LAC/USC Hospital
- Delivery occurring at or after 20 weeks gestation
- Diagnosis of antenatal hypertensive disorder: gestational hypertension, preeclampsia without severe features, preeclampsia with severe features, superimposed preeclampsia, eclampsia, chronic hypertension
Exclusion
- HELLP Syndrome
- Renal dysfunction (Serum Creatinine \>1.1 in current pregnancy)
- Known liver disease
- Low platelet count (\<50,000 during hospital admission)
- Known sensitivity or allergy to ibuprofen or acetaminophen
- Use of therapeutic doses of anticoagulation
- Postpartum hemorrhage requiring blood transfusion
- Neonate with platelet disorder or thrombocytopenia in breastfeeding mother
Key Trial Info
Start Date :
December 11 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 11 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03824119
Start Date
December 11 2018
End Date
December 11 2022
Last Update
November 6 2020
Active Locations (1)
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1
LA County Hospital/University of Southern California
Los Angeles, California, United States, 90033