Status:
COMPLETED
Efficacy of Zinc on Concurrent Chemo-radiotherapy Induced Taste Alterations
Lead Sponsor:
Dow University of Health Sciences
Conditions:
Taste, Altered
Eligibility:
All Genders
20-60 years
Phase:
PHASE3
Brief Summary
Taste changes are common in cancer patients receiving concurrent chemoradiation which become a significant complaint and a cause of distress and morbidity. Loss of gustatory function further advances ...
Detailed Description
Consecutive Sampling was used. It was a two-stage sampling method. Data was collected from patients visiting the Oncology Section at Atomic Energy Medical Centre Karachi from September 2017 to March 2...
Eligibility Criteria
Inclusion
- Oral cancer patients undergoing concurrent chemotherapy with radiotherapy for the first time as a single treatment modality.
- Patients aged between 20-60 years.
- Radiation planned between 60-70 Gy of external beam radiotherapy.
- Cisplatin as primary chemotherapeutic agent.
Exclusion
- Previous history of radiotherapy or chemotherapy regardless of time.
- Existence of oral lesions such as aphthous ulcers, stomatitis or candidosis at the time of selection.
- Cranial nerve lesions of V, VII, IX and partial or total glossectomy.
- Individuals with nose or ear infections which can influence taste, metabolic or endocrine disorders that may affect taste sensitivity (Sjogren syndrome, hypertension, diabetes mellitus, renal disease, liver disease and thyroid disease).
- Concomitant administration of a drug with Chemoradiation which may affect taste (metronidazole, diuretics and anti-depressants).
- Individuals already on medications associated with taste disturbances such as penicillamine, tetracyclines, quinolones, and bisphosphonates for any existing condition.
- Patients who didn't agree to participate and sign consent form and lack of cooperation
Key Trial Info
Start Date :
December 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 26 2018
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT03824925
Start Date
December 1 2016
End Date
November 26 2018
Last Update
January 31 2019
Active Locations (1)
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1
Dow University of Health Sciences
Karachi, Sindh, Pakistan, 76000