Status:
COMPLETED
The Comparison of Knee Osteoarthritis Treatment With Bone Marrow Aspirate Concentrate , Leukocyte Rich Platelet Rich Plasma and Hyaluronic Acid
Lead Sponsor:
Clinical Center of Vojvodina
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
The aim of this study is to compare therapeutic and clinical effects of intra-articular injection of Bone Marrow Aspirate Concentrate (BMAC), inta-articular injection of Leukocyte Rich Platelet Rich p...
Detailed Description
Osteoarthritis (OA) is the most common joint disease worldwide, affecting an estimated 10% of men and 18% of women over 60 years of age with the knee and hip joints predominantly involved. The pain an...
Eligibility Criteria
Inclusion
- history of complaints of knee pain because of the Knee Osteoarthritis with no relief using anti-inflammatory agents even after 3 months,
- Kellgren-Lawrence (KL) grade 2-4
- normal blood results and coagulation profile (platelets 150,000-450,000/l),
- patients who had not undergone any surgery on the affected knee within 2 years prior to the first injection and
- Mentally fit for clinical study
Exclusion
- severe knee instability,
- severe misalignment,
- unicompartmental OA
- BMI more than 35
- inflammatory arthritis such as rheumatoid arthritis and ankylosing spondylitis
- presenting muscle pain underlying diseases such as hematologic disorders, septicemia, coagulopathy, neoplasm, active infection, and immune deficiency
Key Trial Info
Start Date :
April 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2017
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT03825133
Start Date
April 1 2016
End Date
November 30 2017
Last Update
February 7 2019
Active Locations (1)
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1
Clinical Center of Vojvodina
Novi Sad, Vojvodina, Serbia, 21137