Status:
WITHDRAWN
A Gene Therapy Trial to Evaluate the Safety and Efficacy of RP-L201 in Subjects With Leukocyte Adhesion Deficiency-I
Lead Sponsor:
Rocket Pharmaceuticals Inc.
Conditions:
Leukocyte Adhesion Defect - Type I
Eligibility:
All Genders
3+ years
Phase:
PHASE1
Brief Summary
The primary purpose of the Phase I portion of the study is to determine the safety profile and preliminary evidence of efficacy associated with infusion of autologous gene-corrected hematopoietic stem...
Detailed Description
The study is a pediatric non-randomized open-label Phase I clinical trial. This will include a safety evaluation and preliminary assessment of the efficacy of hematopoietic gene therapy consisting of ...
Eligibility Criteria
Inclusion
- A confirmed diagnosis of severe LAD-I as demonstrated by flow cytometry indicating CD18 expression on \<2% neutrophils (polymorphonuclear neutrophils \[PMNs\]). (Patients in which CD18+ PMNs are \>2% will be considered eligible with \<2% CD11a or CD11b expressing PMNs and if there is a documented ITGB2 mutation and clinical history consistent with LAD-I (or known family history).
- At least one (1) prior significant bacterial or fungal infection (US National Cancer Institute \[NCI\] Common Terminology Criteria for Adverse Events \[CTCAE\], v5.0, Grade ≥2). This criteria is not required for patients with documented family history who meet the above inclusion criteria.
- Age ≥3 months.
- Considered to be an appropriate candidate for autologous transplantation of HSCs.
- A competent custodial parent with legal capacity to execute an Ethics Committee (EC)-approved consent form must be available to participate in the consent process. (Informed assent will be sought from capable patients, in accordance with the directive of the EC and with local requirements.)
- Ability to comply with trial procedures including investigational therapy and follow-up evaluations.
Exclusion
- Availability of a medically-eligible human leukocyte antigen (HLA)-identical sibling donor transplant. Patients may not be included in this trial as an alternative to a clinically-indicated and feasible HLA-matched sibling donor HSC transplant. If an HLA-identical sibling is identified, but mobilized peripheral blood or bone marrow HSC collection is not feasible (for example: donor is in utero, is a newborn from whom cord blood was not collected, or is unable to undergo donation procedure because of medical impairments), then inclusion may be permitted per the Principal Investigator discretion.
- Hepatic dysfunction as defined by either:
- Bilirubin \> 1.5 × the upper limit of normal (ULN) or
- Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>2.5×ULN
- Pulmonary dysfunction as defined by either:
- Need for supplemental oxygen during the prior 2 weeks (in absence of acute infection).
- Oxygen saturation (by pulse oximetry) \<90%.
- Evidence of active metastatic or locoregionally advanced malignancy (including hematologic malignancy) for which survival is anticipated to be less than 3 years.
- Serious infections with persistent bloodstream pathogens at time of trial entry. (Patients with active infections \[e.g., unresolved ulcerative lesions, skin or oral infections\] are permitted as long as appropriate antibiotic therapy has been \[or is being\] administered).
- Any medical or other contraindication for both leukopheresis and bone marrow harvest procedure, as determined by the treating investigator.
- Any medical or other contraindication for the administration of conditioning therapy, as determined by the treating investigator.
- Significant medical conditions, including documented human immunodeficiency virus (HIV) infection, poorly-controlled diabetes, poorly-controlled hypertension, poorly-controlled cardiac arrhythmia or congestive heart failure; or arterial thromboembolic events (including stroke or myocardial infarction) within the 6 prior months.
- Any medical or psychiatric condition that in the opinion of the Principal Investigator renders the patient unfit for trial participation or at higher than acceptable risk for participation.
- Patients who are evaluated for the trial and determined ineligible may be subsequently evaluated and declared eligible if the criteria by which they were considered ineligible is reversible (for example: bloodstream infection, transient increase in liver enzymes) and there is documented and plausible evidence of its resolution in the opinion of the Principal Investigator.
Key Trial Info
Start Date :
April 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2021
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03825783
Start Date
April 15 2019
End Date
October 1 2021
Last Update
December 7 2021
Active Locations (1)
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1
Hospital Infantil Universitario Niño Jesús (HIUNJ)
Madrid, Spain, 28009