Status:
RECRUITING
Epinephrine Dose: Optimal Versus Standard Evaluation Trial
Lead Sponsor:
Unity Health Toronto
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Pfizer
Conditions:
Cardiac Arrest, Out-Of-Hospital
Sudden Cardiac Arrest
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The objective of this randomized controlled trial is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine during resuscitation fr...
Detailed Description
This study is designed as a prospective, multicentre, single-blinded randomized controlled trial (RCT) where eligible OHCA patients are randomized to receive a low cumulative dose of epinephrine (low ...
Eligibility Criteria
Inclusion
- Out-of-hospital cardiac arrest treated by paramedics
- Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or witnessed by EMS (paramedic or fire)
- Established intravenous vascular access
Exclusion
- Known or apparent age \<18 years
- Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or confirmed by paramedics
- Cardiac arrest due to an obvious non-cardiac primary cause (e.g. blunt or penetrating trauma, exsanguination, burns, drug overdose, drowning, anaphylaxis, sudden asphyxiation, etc.)
- Administration of intramuscular, endotracheal tube, or intraosseous epinephrine
- Prisoners or persons in police custody
- Known allergy or sensitivity to epinephrine
Key Trial Info
Start Date :
May 24 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
3790 Patients enrolled
Trial Details
Trial ID
NCT03826524
Start Date
May 24 2023
End Date
December 1 2028
Last Update
December 11 2025
Active Locations (8)
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1
British Columbia Emergency Health Services (BCEHS)
Victoria, British Columbia, Canada, V8W 9P1
2
Peel Regional Paramedic Services
Brampton, Ontario, Canada, L6T 4B9
3
Middlesex-London Paramedic Service
London, Ontario, Canada, N6E 1R4
4
Halton Region Paramedic Services
Oakville, Ontario, Canada, L6M 3L1