Status:
UNKNOWN
Comparative Study of Human Immunodeficiency Virus Negative Host Talaromyces Between Voriconazole and Amphotericin Sequential Itraconazole Therapy
Lead Sponsor:
Guangxi Medical University
Collaborating Sponsors:
First Affiliated Hospital of Guangxi Medical University
Second Affiliated Hospital of Guangzhou Medical University
Conditions:
Talaromyces in Human Immunodeficiency Virus Negative
To Compare Voriconazole and Amphotericin Sequential Itraconazole Therapy
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Through a multi-center large-sample non-randomized controlled study, the effect of voriconazole, amphotericin B sequential itraconazole therapy on Talaromyces in Human Immunodeficiency Virus（HIV）negat...
Eligibility Criteria
Inclusion
- HIV-negative adults (≥18 years of age) who diagnosis of talaromyces that was confirmed by either microscopy or culture
- Must be able to swallow tablets
Exclusion
- Pregnancy, central nervous system involvement assessed either clinically or by analyses of cerebrospinal fluid
- An allergy to voriconazole, itraconazole or amphotericin
- The concomitant use of certain medications that interact with voriconazole, itraconazole or amphotericin
- An alanine aminotransferase or aspartate aminotransferase level of more than 400 U per liter
- An absolute neutrophil count of less than 500 per cubic millimeter
- A creatinine clearance of less than 30 ml per minute (calculated by the method of Cockcroft and Gault)
- a concurrent diagnosis of cryptococcal meningitis
- concurrent treatment with rifampicin
- previous treatment for talaromyces for more than 48 hours
- HIV positive who diagnosis of talaromyces.
Key Trial Info
Start Date :
December 30 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2021
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03827278
Start Date
December 30 2018
End Date
December 30 2021
Last Update
February 5 2019
Active Locations (1)
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1
Guangxi Medical University
Nanning, Guangxi, China, 530021