Status:
UNKNOWN
Diagnosis of Colorectal Cancer and Advanced Adenoma Using Cancer-specific Methylation Signatures
Lead Sponsor:
Shanghai Zhongshan Hospital
Collaborating Sponsors:
West China Hospital
Guangzhou First People's Hospital
Conditions:
Colorectal Cancer
Advanced Adenoma
Eligibility:
All Genders
45-80 years
Brief Summary
Colorectal cancer is a common malignant tumor of the digestive tract. It is still a challenging task to detect colorectal cancer at an early stage. Studies have found that DNA methylation has a relati...
Detailed Description
1. Research Background 1.1 Diagnosis of colorectal cancer Colorectal cancer is a common malignant tumor of the digestive tract. According to statistics from 2015, both morbidity and mortality of c...
Eligibility Criteria
Inclusion
- Age 45\~80 years old, gender is not limited, women are not in pregnancy and lactation;
- Willing to accept a full colonoscopy;
- The patients enrolled are newly diagnosed patients who did not receive surgery, radiotherapy, chemotherapy, targeted therapy or other tumor-related intervention;
- The anticoagulant drugs such as warfarin, aspirin and Plavix were stopped for 1 week, and low molecular weight heparin was stopped on the same day;
- No history of other cancer diseases, normal liver and kidney function;
- No major trauma requiring blood transfusion treatment occurred within one week.
Exclusion
- Have had colorectal cancer or intestinal adenoma before;
- Have other cancer history;
- Previously undergoing a colon and rectal resection (except for sigmoid diverticulosis);
- Patients with Lynch syndrome in the family;
- History of severe cardiovascular disease (eg previous myocardial infarction, coronary artery bypass grafting or coronary stenting, history of congestive heart failure; myocardial infarction within 6 months, uncontrolled severe hypertension, etc.), or patients that the investigator determines not suitable for enrollment;
- Participated in "interventional" clinical trials and have taken test drugs over the past 30 days;
- Patients that the investigator determines not suitable for enrollment;
- Failure to follow the test plan to collect blood on time;
- The blood collection sample does not meet the requirements.
Key Trial Info
Start Date :
October 26 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2020
Estimated Enrollment :
1300 Patients enrolled
Trial Details
Trial ID
NCT03828396
Start Date
October 26 2018
End Date
September 30 2020
Last Update
February 4 2019
Active Locations (1)
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1
Shanghai Zhongshang Hospital
Shanghai, Shanghai Municipality, China