Status:
COMPLETED
The Impact of Cytochrome P450 Abnormalities in Patients With Delirium.
Lead Sponsor:
Wake Forest University Health Sciences
Conditions:
Delirium, Cytochrome P-450 Enzyme System
Eligibility:
All Genders
18-99 years
Brief Summary
Objectives: 1. To examine whether patients with delirium have higher prevalence of cytochrome-P450 abnormalities compared to patients without delirium. 2. To examine whether the severity of delirium ...
Detailed Description
Delirium is a costly and devastating illness affecting older patients in the hospital. Its prevalence increases as patients get older and sicker. There is scientific evidence that delirium affects cog...
Eligibility Criteria
Inclusion
- Patients age 18 and older admitted to the ALGH (Advocate Lutheran General Hospital) rehabilitation unit
- One or more of the Following Principle Diagnosis:
- Principle stroke diagnosis Principle Cardiac-Post cardiac surgery Principle Spinal surgery
- Non-English speakers are not anticipated. However, there is an available interpreter services already on the unit and this interpreter's services will be utilized. https://www.languageline.com/ However, we will utilize that AHC IRB approved short forms if a potential subject presents itself.
Exclusion
- Stroke patients with any diagnosed aphasia
- Spinal surgery, as a result of trauma
- Pregnant women
- Prisoners
- Patients with dementia (score of greater than 3.3 on short IQCODE questionnaire) (Long Term Cognitive Impairment after Critical Illness, NEJM, 2013, Pandharipande et al.)
- Patients with cirrhosis and liver failure
- Patients with renal failure requiring dialysis
- Recent blood transfusion
Key Trial Info
Start Date :
January 31 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 24 2020
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT03829670
Start Date
January 31 2019
End Date
June 24 2020
Last Update
October 4 2024
Active Locations (1)
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1
Advocate Health Care
Park Ridge, Illinois, United States, 60068