Status:
COMPLETED
The Effects of Light on Glucose Metabolism
Lead Sponsor:
Maastricht University
Collaborating Sponsors:
Maastricht University Medical Center
Conditions:
Diabetes Mellitus, Type 2
Glucose Intolerance
Eligibility:
All Genders
40-75 years
Phase:
NA
Brief Summary
This study evaluates the effect of bright light on postprandial blood glucose metabolism in obese subjects with impaired fasting glucose and/or impaired glucose tolerance.
Detailed Description
Light has a major influence on the biological clock and several studies suggest that bright light during the day and dim light in the evening are beneficial for the circadian timing system. Nowadays, ...
Eligibility Criteria
Inclusion
- Caucasian
- BMI 25-35 kg/m2
- Stable weight (+/- 3 kg in the last 3 months)
- One of the four criteria for prediabetes:
- Impaired fasting glucose (6.1 mM to 6.9 mM)
- Blood glucose values 7.8 - 11.1 mM 2h after glucose drink consumption during the oral glucose tolerance test (OGTT) in screening
- Insulin Resistance: glucose clearance rate ≤ 360 ml/kg/min, as determined using the oral glucose insulin sensitivity (OGIS120) index
- HbA1c of 5.7 - 6.4%.
Exclusion
- Fasting plasma glucose ≥7.0 mM
- Blood donation one month prior to study and three months after finishing study.
- Participants with extreme chronotypes (going to bed extremely late/early).
Key Trial Info
Start Date :
July 13 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 7 2020
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT03829982
Start Date
July 13 2018
End Date
February 7 2020
Last Update
September 24 2020
Active Locations (1)
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1
Maastricht University
Maastricht, Limburg, Netherlands, 6229 ER