Status:
COMPLETED
Identifying Strategies to Alleviate Cardiovascular Stress in Coronary Patients During Heatwaves
Lead Sponsor:
Montreal Heart Institute
Collaborating Sponsors:
National Health and Medical Research Council, Australia
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
The purpose of this study is to determine the optimal cooling strategies to alleviate cardiovascular strain of coronary artery disease individuals during a simulated North American and Australian heat...
Detailed Description
Globally, heatwaves are occurring more frequently, are of greater intensity and longer in duration. The devastating health impacts of extreme heat are increasingly recognized, particularly in vulnerab...
Eligibility Criteria
Inclusion
- History of angiographic coronary disease (≥70% arterial diameter narrowing of at least one major epicardial coronary artery) and/or prior coronary revascularization and/or documented prior acute coronary syndrome and/or stable angina and/or perfusion defect during exercise testing.
- No CAD-related hospitalisations or changes in cardiac medications or change in pattern of angina for at least 3 months prior to enrolment
Exclusion
- Body mass index ≥35 kg/m2.
- Currently undertaking estrogen therapy.
- Evidence of current fluid and electrolyte disorders, anemia, abnormal thyroid function, arrhythmias, diabetes, renal disease, liver disease, cerebrovascular disease, significant pulmonary disease, endocrine abnormalities, significant cognitive impairment, psychiatric disorder, substance abuse, degenerative neurological condition or any other medical condition deemed to pose risk during the proposed experiments.
- Uncontrolled hypertension (\>180/110 mmHg).
- Recent (\<3 months) coronary bypass surgery.
- Ejection fraction \<40% and/or clinical evidence/history of heart failure.
- Significant valvular heart disease
- Resting ECG abnormalities interfering with observation of ST segment changes during testing.
Key Trial Info
Start Date :
February 18 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 23 2021
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT03832504
Start Date
February 18 2019
End Date
June 23 2021
Last Update
August 1 2023
Active Locations (1)
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1
cardiovascular Prevention and rehabilitation Centre of the Montreal Heart Institute
Montreal, Quebec, Canada, H1T1N6