Status:
UNKNOWN
The United Kingdom Thrombotic Thrombocytopenic Purpura Registry (UK TTP Registry)
Lead Sponsor:
University College, London
Conditions:
TTP - Thrombotic Thrombocytopenic Purpura
Eligibility:
All Genders
Brief Summary
This is a UK (United Kingdom) based registry, involving all sites treating newly presenting Thrombotic Thrombocytopenic Purpura (TTP). From this registry, important epidemiological data will be obtain...
Detailed Description
The UK TTP registry started in January 2009, following 3 years MRC funding, involving UK collaboration from all sites treating TTP patients. It has resulted in a cohort of data and samples from UK TTP...
Eligibility Criteria
Inclusion
- Patients with a clinical diagnosis of TTP, defined by thrombocytopenia, MAHA which may be associated with clinical evidence of organ compromise.Confirmed by severely reduced ADAMTS13 levels and/or a positive antibody screen.
- No age restriction.
- Consent for addition to the Registry and collection/storage of admission information once in remission.
- Consent to collect, analyse and store EDTA sample once in remission.
- Consent to store samples once in remission (sample taken as part of standard care).
- For sites undertaking ADAMTS13 analysis, consent to send admission and remission samples for analysis relating to TTP.
- Follow up laboratory and clinical data at least yearly to identify any changes.
Exclusion
- Patients with cancer or transplant associated MAHA will not be included.
- Patients not wishing to be involved with the registry.
Key Trial Info
Start Date :
January 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2023
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT03832881
Start Date
January 1 2009
End Date
November 1 2023
Last Update
February 6 2019
Active Locations (1)
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1
University College London Hospital
London, United Kingdom, NW1 2PG