Status:
UNKNOWN
Oestradiol Supplementation in Luteal Long Agonist Fresh In Vitro Fertilization/Intra Cytoplasmic Sperm Injection ( IVF/ICSI) Cycle .
Lead Sponsor:
Cairo University
Conditions:
Infertility
Eligibility:
FEMALE
20-38 years
Phase:
PHASE3
Brief Summary
Whether oestradiol administration affects the pregnancy rate in long agonist fresh IVF/ICSI cycles. Oestradiol level will be measured the day of HCG trigger to assess whether oestradiol level affects ...
Detailed Description
6\. Background and Rationale: Progesterone is essential for successful implantation and maintenance of early pregnancy . Although the oestrogen is not essential, it is important to maintain the proges...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Age group 20-38 years old.
- Patients Undergoing gonadotropin Releasing Hormone (Gn RH) long agonist protocol, with fresh embryo transfer.
- Day 3 Grade 1 embryos.
- Trilamellar endometrium with ranging endometrial thickness from 8 mm to 14 mm.
- Exclusion criteria:
- Karyotypic abnormalities in either partner.
- Patients with uterine abnormalities.
- G3-G4 quality embryos.
- Estradiol level 10,000 or more at time of trigger.
- Cases of egg donation/sperm donation/embryo donation.
- Polycystic ovary syndrome (PCOS )patients.
- Poor responders (maternal age \>40, Antral follicle counts (AFC )\<5, Anti Mullerian Hormone (AMH )\<1 and previous trial \<5 oocyte retrieved ) (bologna criteria 2011)
- Those with 3 or more implantation failure.
- Endometrial thickness \<8 or \>14mm.
- Severe male factor.
Exclusion
Key Trial Info
Start Date :
December 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2020
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT03832894
Start Date
December 1 2018
End Date
January 1 2020
Last Update
February 7 2019
Active Locations (1)
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1
Art Unit/ Obatetrics and Gynecology Department
Cairo, Cair0, Egypt, 11542