Status:
COMPLETED
Effects of Iron Therapy in Heart Failure With Preserved Ejection Fraction and Iron Deficiency (PREFER-HF)
Lead Sponsor:
Institut de Recerca Biomèdica de Lleida
Collaborating Sponsors:
Fundació La Marató de TV3
Conditions:
Heart Failure With Normal Ejection Fraction
Ferropenic Anemia
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of the study is to evaluate whether the administration of iron to patients with heart failure and preserved ejection fraction results in an improvement of symptoms and functional class, in...
Detailed Description
Iron deficiency is one of the most prevalent co-morbid conditions in chronic heart failure. In the absence of any iron treatment, it is estimated that up to 50% of patients with heart failure have low...
Eligibility Criteria
Inclusion
- Subjects with stable chronic HF (NYHA II/IV functional class) on optimal background therapy (as determined by the investigator) for at least 4 weeks with no dose changes of heart failure drugs during the last 2 weeks (with the exception of diuretics). In general, optimal pharmacological treatment should include an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker and a beta blocker unless contraindicated or not tolerated and diuretic if indicated.
- Left ventricular ejection fraction \>45% (value within 3 months of planned date of randomization).
- BNP \>100 pg/mL and/or N-terminal-pro-BNP \>400 pg/mL at the screening visit.
- Subject must be capable of completing the 6 minute walking test
- Screening serum ferritin \<100 ng/mL or 100-300 ng/mL with transferrin saturation \<20%.
- At least 18 years of age.
- Before any study-specific procedure, the appropriate written informed consent must be obtained.
Exclusion
- Subject has known sensitivity to any of the products to be administered during dosing.
- History of acquired iron overload.
- History of erythropoietin-stimulating agent, i.v. iron therapy, and/or blood transfusion in previous 6 weeks prior torandomization.
- Oral iron therapy at doses \>100 mg/day in previous 1 week prior to randomization. Note: ongoing use of multivitamins containing iron \<75 mg/day is permitted.
- Exercise training programme(s) in the 3 months prior to screening or planned in the next 6 months.
- Known active bacterial infection.
- Chronic liver disease (including active hepatitis) and/or screening alanine transaminase or aspartate transaminase above three times the upper limit of the normal range.
- Subjects with known hepatitis B surface antigen positivity and/or hepatitis C virus ribonucleic acid positivity.
- Vitamin B12 and/or serum folate deficiency. If deficiency-corrected subject may be rescreened for inclusion.
- Subjects with known seropositivity to human immunodeficiency virus.
- Clinical evidence of current malignancy with exception of basal cell or squamous cell carcinoma of the skin, and cervical intraepithelial neoplasia.
- Currently receiving systemic chemotherapy and/or radiotherapy.
- Renal dialysis (previous, current, or planned within the next 6 months).
- Unstable angina pectoris as judged by the investigator; severe valvular or left ventricular outflow obstruction disease needing intervention; atrial fibrillation/flutter with a mean ventricular response rate at rest \>100 beats per minute.
- Acute myocardial infarction or acute coronary syndrome, transient ischemic attack, or stroke within the last 3 months prior to randomization.
- Coronary artery bypass graft, percutaneous intervention (e.g. cardiac, cerebrovascular, and aortic; diagnostic catheters are allowed), or major surgery, including thoracic and cardiac surgery, within the last 3 months prior to randomization.
- Subject currently is enrolled in or has not yet completed at least 30 days since ending other investigational device or drug study(ies), or subject is receiving other investigational agent(s).
- Subject of childbearing potential who is pregnant (e.g. positive human chorionic gonadotropin test) or is breastfeeding.
- Subject will not be available for all protocol-specified assessments.
- Subject has any kind of disorder that compromises the ability of the subject to give written informed consent and/or to comply with study procedures.
Key Trial Info
Start Date :
August 23 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 20 2024
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT03833336
Start Date
August 23 2017
End Date
December 20 2024
Last Update
May 21 2025
Active Locations (2)
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1
Hospital Universitari Arnau de Vilanova
Lleida, Lleida, Spain
2
Hospital de Manises
Manises, Valencia, Spain