Status:
UNKNOWN
Dental Pulp Regeneration by Autologous Tissue Transplantation
Lead Sponsor:
University of California, Los Angeles
Conditions:
Dental Pulp Regeneration
Eligibility:
All Genders
7-50 years
Phase:
NA
Brief Summary
The purpose of this study is to develop new improved therapy for teeth that require root canals due to tooth infection or tooth inflammation. Investigators will recruit total of 50 participants from t...
Detailed Description
The goal of the study is to test whether autologous pulpal mesenchymal stem cells (MSCs) is capable of de novo regeneration of pulp-dentin complex and restoration of normal pulp physiology in teeth wi...
Eligibility Criteria
Inclusion
- Healthy male or female participants at ages of 7 - 50 y.o. presenting with a tooth diagnosed with complete or partial necrosis of the pulp or irreversible pulpitis.
- Participants presenting with donor pulp tissue, either from existing deciduous teeth or from permanent teeth treatment planned for extraction, e.g., second premolars for orthodontic extraction or third molars.
- Participants presenting with irreversible pulpitis and partial necrosis, i.e., visible pulpal tissues during access opening and canal debridement.
- Participants with immature root apices, including those with partially closed apex, that require root canal procedure.
Exclusion
- Participants with any systemic conditions preventing routine dental procedures or requiring medication that interfere with healing or induce bleeding.
- Participants with avulsed, replanted teeth with resultant pulp necrosis.
- Participants with vertical root fracture/cracks.
- Participants with teeth that are not restorable.
Key Trial Info
Start Date :
February 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2021
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03833401
Start Date
February 1 2019
End Date
June 30 2021
Last Update
February 7 2019
Active Locations (1)
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1
UCLA School of Dentistry
Los Angeles, California, United States, 90095