Status:
UNKNOWN
Metformin in Combined With Cisplatin Plus Paclitaxel With Advanced Esophageal Squamous Cell Carcinoma (ECMTPneo)
Lead Sponsor:
Peking University
Conditions:
Esophageal Squamous Cell Carcinoma
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
This is an open-label phase II trial investigating the effect of metformin in combined with cisplatin plus paclitaxel as neoadjuvant therapy with advanced esophageal squamous cell carcinoma.
Detailed Description
In this prospective phase II study, eligible patients are received cisplatin plus paclitaxel for 2-4 cycles combined with metformin orally. The investigators aim to compare the tumor metabolic pathway...
Eligibility Criteria
Inclusion
- Having signed informed consent.
- Age 18 to 70 years old
- Histologically confirmed esophageal squamous carcinoma
- Computed tomography (CT) or magnetic resonance imaging (MRI) confirmed advanced ESCC which need neoadjuvant chemotherapy before surgical resection.
- Measurable disease according to the Response Evaluation Criteria In Solid Tumors (RECIST) 1.1 criteria(diameter of the lesion should be more than 10mm by spiral CT or MRI, more than 20mm by common CT, the date of image should be less than 21 days before enrollment)
- Life expectancy of ≥3 month
- Eastern Cooperative Oncology Group (ECOG) 0-1
- Body Mass Index (BMI) ≥18.5kg/m2
- WBC\>3,000/mm3, absolute neutrophil count ≥1500/mm3, platelet\>100,000/mm3, Hb\>9g/dl，Bilirubin level \< 1.5 times ULN，Serum creatinine \<1.5 times ULN，ALT and AST\<2.5 times ULN ，AKP \< 2.5 times ULN ，(≤5 times ULN in patients with liver metastases)(within 7 days before enrollment)
- No sever complication, such as active gastrointestinal bleeding, perforation, jaundice, obstruction, non-cancerous fever\>38℃.
- Good compliance
Exclusion
- Have used metformin or biguanide in the past
- Contraindications of metformin
- Unable to take metformin orally because of esophageal stenosis
- Currently receiving other effective regimens
- Previous anticipate other clinical trial within 4 weeks before entering this study
- No measurable lesions, eg. pleural fluid and ascites\\
- Only with other previous malignancy within 5 year, except non-melanoma skin cancer and cervical carcinoma in situ
- Heart failure or other sever organ dysfunction, eg. coronary artery disease, myocardial infarction within the last 6 months only Brain or bone metastasis
- Mentally abnormal or disable cognition,including central nervous system (CNS) metastasis
- HIV infection, active hepatitis B or hepatitis C
- Unstable systemic diseases such as poorly controlled diabetes
- Interstitial lung disease, such as interstitial pneumonia, pulmonary fibrosis, or evidence of interstitial lung disease showed in X-ray/CT
- Known hypersensitivity to study drugs
- Pregnancy or lactation period
Key Trial Info
Start Date :
February 5 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 20 2020
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT03833466
Start Date
February 5 2019
End Date
June 20 2020
Last Update
February 15 2019
Active Locations (1)
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1
Peking Universtiy Cancer Hospital
Beijing, Beijing Municipality, China, 100142