Status:
COMPLETED
The Diurnal Rhythm in Natriuretic Peptide Levels
Lead Sponsor:
University of Alabama at Birmingham
Conditions:
Natriuretic Peptides
Obesity
Eligibility:
MALE
18-40 years
Phase:
NA
Brief Summary
The purpose of the study to assess the diurnal rhythm in natriuretic peptide levels and its temporal relationship with nocturnal blood pressure in obese and African-American individuals as compared wi...
Detailed Description
Obese and African-American individuals are at greater risk for cardiovascular morbidity and mortality than lean and white individuals. One of the key reasons for this health disparity is a higher risk...
Eligibility Criteria
Inclusion
- Age 18 to 40 years
- Blood pressure less than 140/90
- Body Mass Index between 18.5 to 25 kg/m2 (lean) or 30 to 45 kg/m2 (obese)
- Self identified African-American or white individuals
- Willingness to comply with the study diet
- Provide informed consent
Exclusion
- History of hypertension
- History of cardiovascular, renal, or liver disease
- Diabetes or use of glucose-lowering medications
- Use of vasoactive or diuretic medications
- Atrial fibrillation
- Anemia (Hematocrit \<41%)
- Abnormal serum sodium or potassium
- Abnormal liver function tests (\>3x upper limit of normal)
- Current smokers
- Regular users of non-steroid anti-inflammatory medications
Key Trial Info
Start Date :
April 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2021
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT03834168
Start Date
April 1 2019
End Date
March 31 2021
Last Update
February 5 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294