Status:
COMPLETED
Trial to Evaluate the Safety and Immunogenicity of a 20-Valent Pneumococcal Vaccine in Adults 65 Years of Age or Older With Prior Pneumococcal Vaccination
Lead Sponsor:
Pfizer
Conditions:
Pneumococcal Disease
Eligibility:
All Genders
65+ years
Phase:
PHASE3
Brief Summary
This Phase 3 will describe the safety and immunogenicity of a 20-valent pneumococcal conjugate vaccine formulation in adults 65 years of age or older with prior pneumococcal vaccination
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Male or female adults 65 years of age or greater.
- Adults determined by clinical assessment, including medical history and clinical judgment, to be eligible for the study, including adults with preexisting stable disease, defined as disease not requiring significant change in therapy in the previous 6 weeks or hospitalization for worsening disease within 12 weeks before receipt of investigational product.
- Female subject of nonchildbearing potential; male subject not able to father children or who is able to father children and willing to use a highly effective method of contraception.
- Male or female adults who meet 1 of the following:
- Vaccination with PPSV23 greater than or equal to 1 year and less than or equal to 5 years prior to vaccination in the study, and no prior 13vPnC vaccination (Cohort A).
- Vaccination with 13vPnC greater than or equal to 6 months prior to vaccination in the study, and no prior PPSV23 vaccination (Cohort B).
- Vaccination with 13vPnC followed by PPSV23 (PPSV23 vaccination greater than or equal to 1 year prior to vaccination in the study) (Cohort C).
- Exclusion Criteria
- Serious chronic disorder including metastatic malignancy, severe chronic obstructive pulmonary disease (COPD) requiring supplemental oxygen, end-stage renal disease with or without dialysis, clinically unstable cardiac disease, or any other disorder that, in the investigator's opinion, excludes the subject from participating in the study.
- History of microbiologically proven invasive disease caused by S pneumoniae.
Exclusion
Key Trial Info
Start Date :
February 12 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 12 2020
Estimated Enrollment :
875 Patients enrolled
Trial Details
Trial ID
NCT03835975
Start Date
February 12 2019
End Date
February 12 2020
Last Update
February 21 2021
Active Locations (42)
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1
Coastal Clinical Research, Inc.
Mobile, Alabama, United States, 36608
2
East Valley Gastroenterology and Hepatology Associates
Chandler, Arizona, United States, 85224
3
The Pain Center of Arizona
Peoria, Arizona, United States, 85381
4
HOPE Research Institute
Phoenix, Arizona, United States, 85018