Status:
COMPLETED
The Effect of Bread Fortification With Phosphorus and Lysine on Postprandial Glycaemia and Thermogenesis
Lead Sponsor:
American University of Beirut Medical Center
Conditions:
Postprandial Hyperglycemia
Energy Expenditure
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Wheat and wheat derived products are highly consumed around the world. They constitute the major dietary source of protein and energy for many individuals. Wheat contains moderate quantity of low qual...
Detailed Description
Specific Aim 1: Determine the acceptability and assess sensory differences of the fortified breads. White wheat flour will be fortified with either lysine, phosphorus, or both lysine and phosphorus. ...
Eligibility Criteria
Inclusion
- Efforts will be made to age and gender match subjects (balanced number of males and females in each group). Subjects are appropriate if they are in the age range between 18 and 60. Women who are in the reproductive age will be studied at the first half of their menstrual cycle, because estrogen is known to affect the energy expenditure. Postmenopausal women taking hormonal replacement therapy will be excluded. Subjects should have: Cr \<1mg/dl for women and \<1.2mg/dl for men and GFR \>60 ml/min/1.73m2.
Exclusion
- Subjects with diabetes, cardiovascular, cerebrovascular, pulmonary, hepatic, renal, endocrinological (PTH), or any significant medical disease will be excluded.
- Pregnant and lactating women.
- Subjects on regular use of medication that affects body weight and/or having a weight loss of 3% or more in the preceding 3 months.
- Subjects with: Cr \>1mg/dl for women and \>1.2mg/dl for men and GFR\<60 ml/min/1.73m2.
Key Trial Info
Start Date :
February 6 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 20 2020
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT03836495
Start Date
February 6 2019
End Date
May 20 2020
Last Update
October 6 2025
Active Locations (1)
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1
American University of Beirut
Beirut, Lebanon