Status:
COMPLETED
BReast CAncer Genes(BRCA) Expressions in Metastatic Gastric Cancer
Lead Sponsor:
Chung-Ang University
Conditions:
BRCA Gene Rearrangement
Eligibility:
All Genders
19+ years
Phase:
NA
Brief Summary
The investigators evaluated the incidence of BRCA loss in patients with advanced gastric cancer and observed the treatment outcome and prognosis according to BRCA loss. And the investigators evaluated...
Detailed Description
Stomach cancer is still the leading cause of cancer deaths globally and is reported to be the second leading cause of cancer deaths in Korea (18.7%). Although the number of radical resection has incre...
Eligibility Criteria
Inclusion
- Metastatic gastric cancer( Adenocarcinoma)
- Eastern Cooperative Oncology Group (ECOG) performance 0-2
- one more measure lesion
- White blood cell count (WBC) \> 3000/ul , Platelet \> 75,000/ul
- Normal kidney function (serum creatinine \< 1.5 ULN)
- Normal Liver function (Aspartate aminotransferase (AST)/ Alanine aminotransferase (ALT) \< 3 times of upper normal limit, if liver metastasis, AST/ALT \< 5 times of upper normal limit)
- life expectancy is more than 3 months
- Conventional surgery that does not cause the transformation of the target lesion is allowed
- The patient who voluntarily decided to participate in this study and agreed in writing
Exclusion
- Her-2 positive advanced gastric cancer
- Central nervous system metastases requiring treatment with symptoms
- Major uncontrolled cardiovascular disease (including myocardial infarction and congestive heart failure within 6 months)
- Uncontrolled infection or other serious diseases
- Patients with serious medical conditions or serious illnesses
- Patient who is pregnant or lactating
- Adjuvant chemotherapy before 6 months (patients who have not received platinum-based chemotherapy even if they are 6 months old can register)
- In the past, if the primary lesion or target lesion was treated with radiation (if the recurred lesion is outside the range of radiation therapy)
Key Trial Info
Start Date :
August 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03838406
Start Date
August 1 2017
End Date
December 31 2019
Last Update
January 27 2021
Active Locations (1)
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1
Chung-Ang University College of Medicine
Seoul, South Korea, 06973