Status:
COMPLETED
Epigenetic Regulation in Fibrous Dysplasia of Bone: mirDYS Study.
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Fibrous Dysplasia of Bone
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Fibrous dysplasia of bone is a rare congenital but non-hereditary disease caused by a post-zygotic activation mutation of the GNAS gene. Patients with fibrous dysplasia may present pain and bone compl...
Eligibility Criteria
Inclusion
- Control population :
- men and women,
- 18 years-old and over,
- consulting a rheumatologist or an orthopedist for arthrosis
- have scheduled surgery for hip or knee replacement surgery or any intervention involving the lower limb or upper limb.
- Patients with Fibrous dysplasia:
- men and women,
- 18 years-old and over,
- with a diagnosis of fibrous dysplasia previously established by a rheumatologist.
Exclusion
- Refusal to participate in the study
- Long- term corticosteroids treatment (\> 3 months)
- Treated osteoporosis
- Chronic inflammatory rheumatism (rheumatoid arthritis, psoriasic arthritis, spondyloarthropathy)
- Collagen disease (osteogenesis imperfecta…)
- Paget's disease, benign bone tumors
- Uncontrolled hypo/hyper-thyroidism, hypo/hyper-parathryoidism
- Severe renal impairment (GFR \< 30 ml/min/1.73m2)
- Cancer or bone metastases (current or in the past two years)
- Paget disease, benign bone tumor (osteoid osteoma, enchondroma …)
- Malabsorptive disease (Celiac disease, Whipple's disease, intestinal bypass, short bowel syndrome) and inflammatory bowel disease
- Pregnant women or lactating
- Psychiatric disorders
- Difficulty in understanding French
- Not a beneficiary of french social security
- Patients protected by law
Key Trial Info
Start Date :
January 10 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 24 2023
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT03838991
Start Date
January 10 2019
End Date
March 24 2023
Last Update
September 4 2025
Active Locations (1)
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1
Service de Rhumatologie & INSERM U1033, Pavillon F, Hopital Edouard Herriot
Lyon, France, 69437