Status:
RECRUITING
Sleep-dependent Learning in Aging
Lead Sponsor:
University of Massachusetts, Amherst
Conditions:
Sleep
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is th...
Detailed Description
Exp 1: Using neuroimaging, the investigators will consider whether differences in brain areas engaged during memory encoding contribute to age-related changes in sleep-dependent memory consolidation f...
Eligibility Criteria
Inclusion
- Age 18-80 yrs
- Healthy sleeper
- No diagnosed sleep or neurodegenerative disorder
Exclusion
- Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index \>15; a Period-Limb Movement in Sleep index of \>15/hr; sleep-onset latency \> 45 min (indicative of insomnia); or sleep efficiency \< 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation.
- Past diagnosis neurological illness or head injury
- Reported average sleep per night \< 5 or \> 9 hrs
- Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing
- Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants)
- Daily caffeine intake of \> 4 cups (coffee, tea, colas)
- Weekly alcohol intake of \> 10 cups
- Pregnancy or \< 12 months post-partum
- History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score \> 25
- Abnormal sleep (e.g., shift work, travel across \>2 time zones within the past 3 months).
- Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form);
- Score indicative of cognitive dysfunction (subtest scores \< 40)
- Beck Depression Scale score indicative of depression (\> 19).
- Additionally, individuals will be excluded from magnetic resonance imaging studies (Exps 1, 4) for:
- Left handed or ambidextrous
- Claustrophobia
- Presence of metal (thoroughly screened via questionnaire and metal detector)
- Pregnancy
Key Trial Info
Start Date :
July 15 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 15 2025
Estimated Enrollment :
584 Patients enrolled
Trial Details
Trial ID
NCT03840083
Start Date
July 15 2018
End Date
July 15 2025
Last Update
April 3 2025
Active Locations (1)
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1
University of Massachusetts
Amherst, Massachusetts, United States, 01003