Status:
COMPLETED
Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol
Lead Sponsor:
China International Neuroscience Institution
Conditions:
Nociceptive Pain
Analgesic Adverse Reaction
Eligibility:
All Genders
18-65 years
Phase:
PHASE3
Brief Summary
This study purpose to compare analgesia efficiency of propofol combine with sevoflurane with propofol only using index of Nociception (NOX)
Detailed Description
1. Recently study found sevoflurane plays an important role through spinal nerve peptide receptor (NK.1R), glycine receptor (GlyR), neuron nicotinic receptor (nnAChRs), Methyl-1-methyl-1-day aspartate...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Participants were aged 18-65 years old,
- American Society of Anesthesiologists (ASA) physical status I, II or III
- scheduled to have urological surgery(would last longer than 1 h)
- requiring general anesthesia.
- Exclusion criteria:
- refused to participate in this study;
- Unable to communicate normally because of consciousness alterations;
- a history of allergy to opioids
- contraindications to inhalational anesthesia
- a family history of malignant hyperthermia
- a history of alcohol or drug abuse
- received central nervous system-active drugs
- super obese as defined by a body mass index ≥40 kg/m2
- conditions liable to alter the pharmacokinetic and pharmacodynamic behaviors of the intravenous and inhalation anesthetics
- previous head injury
- neurologic
- psychiatric disease
- any disabling central nervous
- cerebrovascular disease
- using psychoactive
- anti-convulsive medications at the time
- unstable angina
- manifested congestive heart failure
- expected difficulty airway management
Exclusion
Key Trial Info
Start Date :
January 20 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2020
Estimated Enrollment :
146 Patients enrolled
Trial Details
Trial ID
NCT03841812
Start Date
January 20 2020
End Date
July 1 2020
Last Update
October 14 2020
Active Locations (1)
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1
Xuanwu Hospital
Beijing, Beijing Municipality, China, 100053