Status:
RECRUITING
Defining the Genetics, Biomarkers and Outcomes for Dilated Cardiomyopathy
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
British Heart Foundation
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Dilated Cardiomyopathy
Cardiovascular Diseases
Eligibility:
All Genders
Up to 99 years
Brief Summary
Finding new ways to diagnose and treat Dilated Cardiomyopathy (DCM) could improve the health and well-being of patients with this condition. The main aim of this research study is to help develop bett...
Detailed Description
This study will recruit patients from a number of hospitals in England and study them over a number of years. The study will be divided in 2 parts. Part 1 will recruit patients with a diagnosis of DCM...
Eligibility Criteria
Inclusion
- PART 1
- Male or female participants of any age
- Capacity to provide informed consent
- Patients with a confirmed diagnosis of DCM
- Affected family members of patients meeting diagnostic criteria for DCM
Exclusion
- DCM attributed to chemotoxicity (from chemotherapeutic agents, drugs of abuse)
- DCM attributed to systemic inflammatory myopathies (eg sarcoid, systemic lupus erythematosus)
- Patients who lack capacity to consent for themselves
- Patients with a confirmed history of coronary artery disease, assessed using standard UK clinical practice guidelines, defined as one or more of the following:-
- \>50% narrowing, any major epicardial coronary artery on invasive or computed tomography coronary angiography
- CMR suggestive of previous myocardial infarction of ≥2 segments of ≥50% infarction of the LV wall
- Previous percutaneous coronary intervention or coronary bypass surgery
- History of primary valvular heart disease or congenital heart disease
- Severe, untreated or untreatable hypertension (systolic blood pressures routinely \>180 mm Hg and/or diastolic blood pressures \>120 mm Hg)
- PART 2
- Inclusion Criteria:
- Males or females of any age
- Capacity to provide informed consent
- Patients with hypokinetic non-dilated cardiomyopathy, or
- Family members of DCM patients with possible or probable DCM or
- Patients with a confirmed diagnosis of heritable cardiovascular disease or
- Family members of patients with heritable cardiovascular disease, both affected and unaffected
Key Trial Info
Start Date :
January 9 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 22 2027
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT03843255
Start Date
January 9 2020
End Date
July 22 2027
Last Update
March 31 2022
Active Locations (6)
Enter a location and click search to find clinical trials sorted by distance.
1
Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom, LS1 3EX
2
Glenfield Hospital
Leicester, United Kingdom, LE3 9QP
3
Liverpool Heart and Chest Hospital NHS Foundation Trust
Liverpool, United Kingdom, L14 3PE
4
Royal Brompton & Harefield NHS Foundation Trust
London, United Kingdom, SW3 6NP