Status:
UNKNOWN
Exercise-induced Ischemia and the Influence of Pain Modulation in a Nerve Growth Factor (NGF) Model
Lead Sponsor:
Aalborg University
Conditions:
Pain Response
Hyperalgesia
Eligibility:
All Genders
18-55 years
Phase:
EARLY_PHASE1
Brief Summary
The purpose of this study is to investigate responses of pain and the maintenance of mechanical muscle hypersensitivity following an acute exercise-induced ischemic condition repeated over time in a p...
Detailed Description
The hypothesis is that an ischemic conditioning in a NGF-sensitized muscle is able to facilitate pain responses and that over time the pain modulation system is responsible for a subsequent reduction ...
Eligibility Criteria
Inclusion
- Healthy and pain free volunteers
Exclusion
- Pregnancy
- Drug addiction defined as the use of cannabis, opioids or other drugs
- Previous neurologic, mental illnesses, or psychiatric diseases.
- Past history of chronic pain in the musculoskeletal system (muscle, joint, cartilage, connective tissue)
- Participation in other pain trials throughout the study period
- Lack of ability to cooperate
- Taking any analgesic 24 hours before the injections
- Performing any strenuous leg exercise through out the study period causing sore muscles
Key Trial Info
Start Date :
February 18 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2019
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03844243
Start Date
February 18 2019
End Date
June 30 2019
Last Update
February 18 2019
Active Locations (1)
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1
Aalborg University
Aalborg, Denmark, 9220