Status:
TERMINATED
Correlation of FeNO, Blood Eosinophils, Bronchoalveolar Lavage Findings and Bronchial Epithelium Histopathology in Patients With Chronic Obstructive Pulmonary Disease and Asthma
Lead Sponsor:
Heidelberg University
Conditions:
Obstructive Lung Diseases
Eligibility:
All Genders
18+ years
Brief Summary
Scientific research focuses on "eosinophilic inflammation" as it seems to guide the therapeutic regimen in patients with asthma and COPD. The primary objective of this prospective trial is to evaluate...
Detailed Description
This is a multicenter prospective trial. Enrollment will continue until 150 patients with chronic obstructive pulmonary disease and 50 patients with severe asthma have been entered into this trial and...
Eligibility Criteria
Inclusion
- Patients with diagnosis of COPD or asthma (according to the guidelines)
- Age \>18 years
- Indication for bronchoscopy for medical reasons (not study-related)
- Ability to provide informed consent
Exclusion
- paO2 \<60 mmHg on 4L 02 /min, paCO2 \> 55 mmHg on room air
- FEV1 \<20%
- Pulmonary infection or exacerbation within the last 4 weeks
- Additional pulmonary diseases (pneumonia, lung cancer, tuberculosis, interstitial lung disease)
- Contraindication for BAL, PSB sampling or endobronchial biopsy
- Current use of anticoagulants that can not be stopped for bronchoscopy
- Heart failure with left ventricular ejection fraction \<30%
- Myocardial infarction in previous 6 months
- Significant pulmonary hypertension (PAPS \>45 mmHg, right heart failure \[echocardiography\] and/or PAPm \>35 mmHg \[right heart catheter\])
Key Trial Info
Start Date :
February 14 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 8 2020
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT03845257
Start Date
February 14 2019
End Date
January 8 2020
Last Update
July 7 2022
Active Locations (3)
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1
Macquarie University Sydney
Sydney, New South Wales, Australia
2
Division of Clinical Infectious Diseases/Research Center Borstel
Borstel, Germany
3
Thoraxklinik University Heidelberg
Heidelberg, Germany, 69126