Status:
COMPLETED
Pharmacokinetic Study of Vancomycin, Clindamycin And/or Gentamicin Administration During Surgery Using a Microdialysis Procedure
Lead Sponsor:
Poitiers University Hospital
Conditions:
Surgical Site Infection
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
Brief Summary
The surgical site infection is one of the most important causes of postoperative morbidity. The appropriate antibiotic prophylaxis is one of the most effective way to prevent surgical site infections....
Eligibility Criteria
Inclusion
- Adult patient between 18 and 80 years old
- Patient with history of beta-lactam hypersensitivity
- Patient who underwent abdominal or orthopedic surgery whose forseeable time exceeds 1 hour and requires a surgical antibiotic prophylaxis by vancomycin or clindamycin + gentamicin
Exclusion
- morbid obesity (BMI \> 35 kg/m2)
- mild to severe renal impairment (clearance creatinine \< 60 ml/min)
- vancomycin, clindamycin or gentamicin hypersensitivity
- pregnancy
Key Trial Info
Start Date :
May 26 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 4 2024
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT03845790
Start Date
May 26 2019
End Date
September 4 2024
Last Update
January 16 2025
Active Locations (1)
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1
CHU de Poitiers
Poitiers, France