Status:
COMPLETED
Individualized Hemodynamic Optimization by Indirect Measurement of the Respiratory Quotient in Major Surgery: Prospective Randomized Multicentre Open-Label Study (OPHIQUE) Individualized Optimization by Indirect Measurement of the Respiratory Quotient
Lead Sponsor:
Centre Hospitalier Universitaire, Amiens
Collaborating Sponsors:
st isabelle health center, abbeville
Centre Hospitalier Universitaire de Caen
Conditions:
Post-Op Complication
Respiratory Complication
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The measurement of the inspired / expired fractions in O2 and CO2 is part of the daily monitoring of the intubated-ventilated patient in the operating theater. The ratio of VCO2 to VO2 (respiratory qu...
Detailed Description
• Background : The measurement of the inspired / expired fractions in O2 and CO2 is part of the daily monitoring of the intubated-ventilated patient in the operating theater. Changes in EtCO2 may refl...
Eligibility Criteria
Inclusion
- Abdominal, orthopedic or vascular surgery with general anesthesia
- ASA score ≥ II
- Estimated duration of surgery\> 2 hours
- Consent signed.
- Affiliation to a social security scheme
Exclusion
- Untreated or unbalanced severe hypertension under treatment.
- Preoperative renal failure dialyzed.
- Acute heart failure.
- Acute coronary insufficiency.
- Vascular surgery with kidney plasty.
- Cardiac surgery.
- Permanent laparoscopy.
- Preoperative shock state.
- Refusal of patient's participation
- Pregnant woman, parturient or breastfeeding.
- Patient under guardianship or trusteeship, under the protection of justice or private public law.
- Anesthesia with loco-regional anesthesia (spinal anesthesia and epidural).
- Acute respiratory distress syndrome (PaO2 / FiO2 ratio \<300).
- Chronic Respiratory Failure with Home Oxygen Therapy.
- Patient already included in another therapeutic trial with an experimental molecule.
- Emergency anesthesia
Key Trial Info
Start Date :
December 26 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 26 2023
Estimated Enrollment :
350 Patients enrolled
Trial Details
Trial ID
NCT03852147
Start Date
December 26 2018
End Date
January 26 2023
Last Update
September 22 2025
Active Locations (1)
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1
BAR
Amiens, France, 80054