Status:
COMPLETED
Influence of Respiratory Mechanics on Diaphragmatic Dysfunction in COPD Patients Who Have Failed NIV (RHYDIAN)
Lead Sponsor:
University of Modena and Reggio Emilia
Conditions:
Diaphragm Dysfunction
COPD Exacerbation
Eligibility:
All Genders
18+ years
Brief Summary
Although non-invasive mechanical ventilation (NIV) is the gold standard treatment for patients with acute exacerbation of COPD (AECOPD) who develop respiratory acidosis, failure rate are still high ra...
Eligibility Criteria
Inclusion
- age over 18 years
- AECOPD with respiratory acidosis admitted to the Respiratory Intensive Care Unit of the University Hospital of Modena (Italy) undergoing endotracheal intubation due to NIV failure.
Exclusion
- history of neuromuscular disease,
- presence of chest wall deformities,
- coexistence of interstitial lung disease,
- presence of pulmonary edema,
- severe hemodynamic instability,
- septic shock,
- evidence of lobar pneumonia or bilateral parenchymal consolidation at chest X-ray on admission,
- contraindication to NIV,
- previously assessed diaphragmatic palsy,
- intracranial hypertension,
- known pregnancy,
- need for immediate endotracheal intubation,
- neurologic impairment,
- lack of collaboration,
- unreliable maneuver to calculate maximal transdiaphragmatic pressure.
Key Trial Info
Start Date :
January 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2022
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03852394
Start Date
January 1 2017
End Date
March 1 2022
Last Update
April 7 2022
Active Locations (1)
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1
University Hospital of Modena Policlinico di Modena
Modena, Italy