Status:
COMPLETED
Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium
Lead Sponsor:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Conditions:
Postpartum Hemorrhage
Eligibility:
FEMALE
19-50 years
Phase:
NA
Brief Summary
Poor uterine tone after the birth of a baby may cause serious bleeding (called postpartum hemorrhage or PPH). This is a major cause of maternal death worldwide. In the developed world the cesarean sec...
Detailed Description
There is an increasing need to fully understand the mechanisms that contribute to the higher blood loss after general anesthesia during cesarean section therefore it is important the investigators ide...
Eligibility Criteria
Inclusion
- Patients who give written consent to participate in this study
- Patients with gestational age 37-41 weeks
- Patients of 19-50 years
- Non-laboring patients, not exposed to exogenous oxytocin
- Patients requiring primary Cesarean section or first repeat Cesarean section
- Patients undergoing Cesarean section under spinal anesthesia
Exclusion
- Patients who refuse to give written informed consent
- Patients who require general anesthesia
- Patients who had previous uterine surgery or more than one previous Cesarean section
- Patients with any condition predisposing to uterine atony and postpartum hemorrhage, such as abnormal placentation, multiple gestation, preeclampsia, macrosomia, polyhydramnios, uterine fibroids, bleeding diathesis, chorioamnionitis, or a previous history of postpartum bleeding
- Emergency Cesarean section in labor
- Patients on medications that could affect myometrial contractility, such as nifedipine, labetolol or magnesium sulphate.
- Patients who have been exposed to oxytocin prior or during the cesarean section.
Key Trial Info
Start Date :
March 28 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 19 2022
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT03852797
Start Date
March 28 2019
End Date
January 19 2022
Last Update
October 25 2022
Active Locations (1)
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1
Mount Sinai Hospital
Toronto, Ontario, Canada, M5G1X5