Status:
UNKNOWN
Etomidate/Propofol Mixture or Propofol Monotherapy Use in Patients Undergoing General Anesthesia
Lead Sponsor:
Guolin Wang
Conditions:
Etomidate is Mixed With Propofol
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this study was to investigate the effects of different proportions of etomidate/propofol mixture and propofol alone intravenous anesthesia on intraoperative and postoperative physiologi...
Detailed Description
Propofol is one of the most commonly used intravenous anesthesia drugs clinically, the pharmacokinetic characteristics makes it very suitable for total intravenous anesthesia( TIVA), etomidate belongs...
Eligibility Criteria
Inclusion
- Patients undergoing elective general anesthesia surgery in 3h;
- American Society of Anesthesiologists gradesⅠ\~III;
- Aged 18 to 65 years, Body Mass Index 18.5 \~ 29.9kg / m2;
- Hemoglobin 100 \~ 125g / L.
- In line with the ethics, the patients volunteered to take the test and signed the informed consent
Exclusion
- Identify or suspect abuse or chronic use of narcotic sedatives and analgesics;
- Heart, or liver, or lung, or kidney dysfunction;
- Body mass index\> 30kg / m2; or \<18.5kg / m2
- Speech, hearing or mental disorders;
- severe diabetes, hyperkalemia ;
- participate in other drug clinical researches in four weeks;
- Poor compliance, can not complete clinical research by research program.
- Any cerebrovascular accident occurred within 3 months, such as stroke, TIA, etc
- Unstable angina and myocardial infarction occurred within 3 months;
- Having contraindications or allergies to experimental drugs and other narcotic drugs;
- Mental illness, hyperkalemia.
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2019
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03855267
Start Date
January 1 2019
End Date
December 1 2019
Last Update
February 26 2019
Active Locations (1)
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1
Zicheng Wang
Tianjin, Tianjin Municipality, China, 300000