Status:
UNKNOWN
Inhibition of α-synuclein Cell-cell Transmission by NMDAR Blocker, Memantine
Lead Sponsor:
Wayne State University
Conditions:
Parkinson Disease
Eligibility:
All Genders
45-85 years
Phase:
PHASE3
Brief Summary
Lewy Body Dementia (LBD), is the second most common form of dementia after Alzheimer's Disease. Dementia is defined as a serious loss in cognitive ability due to damages or disease in the brain beyond...
Eligibility Criteria
Inclusion
- Diagnosed with idiopathic PD for at least 2 or more years
- 45 to 85 years of age
- Have been on stable doses of anti-Parkinson medication
- Able to give informed consent
- Able to undergo brain MRI
- Unilateral symptoms
- A score of 26 or greater on the Montreal Cognitive Assessment (MOCA), a measure of a patients short-term memory recall, the ability to determine visual-spatial relationships of objects, attention, concentration, working memory, language and orientation to time and place
- Use of one method of medically approved contraceptive
Exclusion
- History of any surgical intervention for treating PD (i.e. deep brain stimulation)
- Extreme physical disability
- History or current diagnosis of unstable psychiatric condition
- Presence of dementia or any other condition that prevents the ability of the participant to provide fully informed consent
- Other brain disease
- Treatment with Memantine 30 days prior to baseline
- Females who are pregnant or nursing
- Presence of interacting medications with Memantine or co-morbid medical conditions that may be exacerbated by this agent
- Moderately significant drug interactions with Dextromethorphan, Amantadine, Sodium Bicarbonate, and Acetazolamide
- Previous Allergic reaction to Memantine
- Any genetic form of PD
Key Trial Info
Start Date :
April 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2023
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03858270
Start Date
April 1 2019
End Date
July 1 2023
Last Update
July 1 2020
Active Locations (1)
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1
Wayne State University
Detroit, Michigan, United States, 48201